Erectile dysfunction (ED),also known as male impotence is type of sexual disorder in men in which a man is not able to get or maintain firm and strong erection for longer duration of time.ED results in unsatisfactory sexual intercourse.

The cause of ED can be physical or psychological. The most common causes include diseases such as diabetes, cardiovascular diseases etc., testosterone deficiency, smoking, drinking alcohol, drug abuse, and lack of physical activity, some medications, obesity, surgery stress, depression, performance anxiety, and frustration.

Medicines like Sildenafil citrate, Tadalafil, Vardenafil, which belong tothe class of phosphodiesterase type 5 (PDE-5) inhibitors, penile pumps, penile implants or penile prosthesis, surgery, lifestyle changes like smoking cessation , alcohol abstinence , nodrug abuse, exercising regularly, and consuming balanced diet., counselling help in treating erectile dysfunction. Sildenafil citrate (Viagra) was the most widely prescribed medicine among PDE-5 inhibitors for treatment of erectile dysfunction.

Sildenafil citrate

Sildenafil citrate is the active component of the brand Viagra. Sildenafil citrate was the first effect oral drug to be approved for the use in ED in the year 1998 by the Food and Drug Administration (FDA).This medicine requires doctor’s prescription.

Mechanism of Action

Sildenafil citrate present in Sildenafil citrate prevents the breakdown of the enzyme cGMP by inhibiting phosphodiesterase type 5 enzyme and thus cause rise in the levels of cGMP.cGMP is required for relaxation of smooth muscles and for dilating the blood vessels inside the penis. The dilated blood vessels allow more blood to enter the penis resulting in stronger erection.

Onset of action and Duration of effect

This medicines takes about 30 to 120 minutes to produces its action on oral administration.The onset of action may vary from person to person. The effect of this medicine continues for an average duration of 4 hours.

Instructions for safe and effective use

The recommended dose of Sildenafil citrate (Generic Viagra) is 100mg daily. This medicine needs to be taken approximately 40 to 60 minutes before having sex.Do not take more or less dose of this medicine and for longer duration than recommended by physician.

It can consumed with meal or without meals. Take the missed dose as soon as you remember

Skip the missed dose if it’s almost the time for next dose. Do not take two doses to compensate for a missed dose.

Give your complete medical history to the medical practitioner before starting this medicine. Patients who are allergic to Sildenafil Citrate should not consume Sildenafil citrate. Avoid concomitant use of Sildenafil citrate with nitrates and blood pressure lowering medicines. Avoid any activity requiring greater mental alertness while taking Sildenafil citrate. Avoid alcohol, grapefruit juice and fatty meals with Sildenafil citrate.

Common Side effects

• Headache

• Vision Disturbances

• Stomach upset

• Flushing

• Nasal Congestion

• Nausea and vomiting

• Drowsiness

• Skin rash

Seek immediate medical help if you experience the following symptoms:

• Chest pain

• Sudden hearing loss

• Sudden vision loss

• Difficulty in breathing

• Irregular heartbeats

• Swelling of face, lips and tongue

• Prolonged and painful erection for more than four hours

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